|J. Chin. Soc. Anim. Sci. 35(Suppl.)|
林德育 陳坤照 張溪泉 王炳煌 黃鈺嘉 吳明哲
AN EXPERIMENTAL INVESTIGATION ON lethal effect of CAPRINE MUCOPOLYSACCHARIDOSIS IIID Gene in Nubian GOAT
D. Y. Lin, K. J. Chen, H. C. Chang, P. H. Wang, Y. C. Huang and M. C. Wu
Livestock Research Institute, Council of Agriculture, Executive Yuan
Caprine Mucopolysaccharidosis IIID is an important inherited deficiency in Nubian goat. It was caused by a point mutation of N-acetylglucosamine 6-sulfatase(G6S) gene. To verified the caprine mucopolysaccharidosis IIID gene effect on surviving rate of Nubian kids, one heterozygote buck of G6S were mated with 12 heterozygote nanny goats in mating season. Eight nannies were pregnant and produced seventeen kids. The pregnant rate and kidding rate were 67%(8/12) and 213%(17/8), respectively. All of these kids were genotyped for G6S. Six kids are normal (TG, test free of G6S), 7 kids are heterozygote (GC, G6S carrier) and 4 kids are affected (G6S). Three of the four affected kids died within two months after birth. Results showed that caprine mucopolysaccharidosis IIID could cause kid died at early stage, and affected the rearing rate of kids.
Key Words: Nubian goat, Caprine Mucopolysaccharidosis, Lethal effect